Synthesis, Characterisation Of Some 2-Azetidinone Derivatives and Evaluation Of Their Antimicrobial Activity

Abstract

In our present study para amino benzoic acid and aniline is condensed with different substituted aromatic aldehydes to form respective Schiff base. It was cyclised with chloro acetyl chloride to yield corresponding azetidinones. Structures of synthesized compounds are confirmed by physical and spectral analysis. The compounds are evaluated for their antimicrobial activities. The activities are due to cyclic CO-NH group in azetidinones. Some of the compounds have shown comparable antimicrobial activities .Out of these synthesized compounds , some of the compound have shown mild to moderate activities , among these one 2-azetidinone having , like AZD.V [N(4((4-chloro)phenyl)-3-chloro-2-azetidinone)phenyl-4-carboxylic acid ] shown good activity in all species except the Saccharomyces cervisea.