Importance of Adhesive Performance of Transdermal Drug Delivery Systems

Abstract

Transdermal drug delivery systems (TDDS) are adhesive patches which deliver the therapeutic agent through the skin at a controlled rate to the systemic circulation and to the target organs (1). These systems provide more convenient and effective therapy compared with the oral and parenteral ways. The most important advantages are improved bioavailability with the avoidance of ‘first pass’ effect of liver and the enzymes in digestive system. Improved patient compliance is provided by controlled delivery of drugs, hence constant blood levels and reduced dosing frequency compared to the conventional oral dosage forms is obtained. Additionally, in some cases like adverse effects the patient has the advantage of removing the patch immediately and also being a non-invasive application makes TDDS more acceptable and accessible for wide range of patient populations (2,3). The advantages of transdermal applications for the patient could be achieved with a well-conceived formulation including polymers, penetration enhancers, rate controlling membranes, adhesives, impermeable backings and also release liners (4).