A Review Article on Superdisintegrants

Abstract

Oral route is mostly considered the best route for administration of solid dosage form. About 85% of solid dosage form administered orally. In improving the drug action Disintegration shows main role. Disintegrants are ingredients added to the drug preparation that enhances the disintegration of the tablet or capsule into reduced particles in aqueous environment that dissolve more quickly than in the nonexistence of disintegrants. Nowadays several newer agents have been highly-developed identified as Superdisintegrants. Superdisintegrants are the ingredients, which facilitate the quicker disintegration with lesser quantity in compare to disintegrants. These have two type’s natural and synthetic superdisintegrants. Superdisintegrants are mostly used at a low level in the solid dosage form, usually 1- 10 % by weight relative to the complete weight of the dosage unit. These are used to increase the effectiveness of solid dosage form. Examples of superdisintegrants are primo gel, crospovidone, Gollan gum etc.