A Comprehensive Review on Gastro-retentive Drug Delivery System

Abstract

The Gastro-retentive Drug Delivery System (GRDDS) is retained in the stomach for prolonged period of time. The gastric residence time is important factor for this system, as it significantly increases the time for which drugs may be released from the formulations. Dosing intervals will be prolonged thus improving patient compliance. The drugs having less half-life and/or bioavailability will be having less effectiveness. The drugs having short half-life will be eliminated from systemic circulation quickly, thus will require frequent dosing of drug formulation to achieve desired therapeutic activity. This is not desirable for the patients having problem in swallowing or specifically in case of paediatric and geriatric patients. GRDDS include various approaches like floating drug delivery system, muco-adhesive drug delivery system, super porous hydrogel systems etc. Along with delivery of drugs, gastro-retentive devices are now-a-days giving novel approaches for various purposes.