Formulation & Evaluation of Sustained Release Mucoadhesive Buccal Patch of Pantoprazole

Abstract

Pantoprazole mucoadhesive bilayer buccal patch was prepared using solvent casting method, 32 factorial design was used to study the effect of concentration changes in XG and PVA, which were selected as independent variables on the swelling index, mucoadhesive time, and invitro release responses. FB13 formulation showed satisfactory results of 226 ± 1.66, 280 ± 2.77, 88.59 ± 2.31 for swelling index, mucoadhesive time, and invitro release respectively. Release kinetics model was fitted in higuchi, with regression value of 0.998. Hence it has been selected as optimized formulation and evaluated for further parameters such as weight uniformity, thickness of patch, folding endurance, surface pH, drug content, mucoadhesive strength. Ex-vivo permeation study on FB13 was carried out in buccal.