Evaluation of male albino rat potentiality via Antioxidant and Steroidogenic enzymes activity in testis under chronic ethanol intoxication

Abstract

Recent days, sexual potential Antioxidant and Steroidogenic enzymes activity abnormalities   in males were major concern in the world wide   Behind this reason, number of factors may be influenced such as smoking, drugs abuse, stress and alcohol consumption. This study was aimed to investigate the potentiality of male rats under ethanol intoxication on rat testis at different doses. The experimental studies were carried out on 40 male rats which were grouped into five, therefore Normal control (NC) received  0.9% NaCl; second to fourth groups have received orally 20% of ethanol ranging doses from  2 g/kg body weight,  4 g/kg and 6 g/kg (b.w) respectively for two month period.  Antioxidant enzymes, Superoxide dismutase (SOD), catalase (CAT) and steroidogenic enzymes such as 3β, 17 β hydroxysteroid dehydrogenase activities measured. 6 g/kg b.w. dose of ethanol has shown high toxic effect on the antioxidant enzymes, steroidogenic enzymes activity which was significantly decreased. In conclusion, we found that 6g/kg dose of alcohol shown drastic changes in testis under chronic exposure and it was also suggested that chronic high dose of alcohol abuse could affect the potentiality of testis that lead to induced infertility.