Formulation and Evaluation of Metformin HCl Floating Tablet using Pectin as a Natural Polymer

Abstract

The present study outlines a systematic approach for design and development of pectin (a natural agent) loaded floating tablets of Metformin HCl to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablet Metformin HCl have been shown sustained release there by proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Five batches of tablets were prepared by the wet granulation by using HPMC-E15 (floating agent) and Pectin (obtained in nature) as polymers along with sodium bicarbonate as gas generating agent. The physicochemical properties of different formulations, their Buoyancy lag time and total floating time and swelling index were evaluated. It was found that the hardness of the tablets were effects the Buoyancy characteristic of the dosage form. All five formulations possessed good floating properties with total floating time between 8 – 12 hrs. The in vitro release studies indicated that the floating dosage forms containing pectin showed slower release. The cumulative % of in vitro drug release of formulation F1, F2, F3, F4, and F5 were 97.5%, 97.98%, 95.47%, 91.42% and 75.50%. Drug release to be enhanced by formulation F4 in compared with the marketed product. The results indicate that gas powered floating tablets of Metformin HCl containing 100mg Pectin provides a better option for sustained release action and improved bioavailability.